Tumor suppressor promotes some acute myeloid leukemias, study reveals
Researchers in Germany have discovered that a tumor suppressor protein thought to prevent acute myeloid leukemia (AML) can actually promote a particularly deadly form of the disease. The study, "RUNX1...
View ArticleCombination immunotherapy effective for advanced prostate cancer
Advanced prostate cancer resistant to castration therapy appears to respond well to a combination of immune checkpoint blockades and treatments that target certain immune-busting cells commonly...
View ArticleGene editing technique helps find cancer's weak spots
Genetic mutations that cause cancer also weaken cancer cells, creating an opportunity for researchers to develop drugs that will selectively kill them, while sparing normal cells. This concept is...
View ArticleNew research shows how metabolism and epigenetics play a role in cancer...
A study published in Briefings in Functional Genomics investigated how epigenetics can modulate human's genetic program—it can emphasize or silence genes. The new research shows that if epigenetics is...
View ArticleResearchers show p300 protein may suppress leukemia in MDS patients
Scientists at Sylvester Comprehensive Cancer Center at the University of Miami Miller School of Medicine have shown that p300, a protein that increases gene expression by attaching acetyl molecules to...
View ArticleResearchers reveal developmental mechanisms behind rare bone marrow disorder
Myelodysplastic syndrome is an umbrella term used to describe disorders characterized by the bone marrow's inability to produce normal blood cells. Researchers from Charité - Universitätsmedizin Berlin...
View ArticleGenetic control of immune cell proliferation
Germinal centers are transient structures in the lymph nodes where antibody-producing B cells proliferate and differentiate at extraordinary rates. Germinal centers can be visually divided into a dark...
View ArticleWhat elephants teach us about cancer prevention
Every time a cell divides, there is a chance for a mutation (mistake) to occur in the DNA - the substance that carries genetic information in all living organisms. These mutations can lead to cancer.
View ArticleScrib protein identified as a natural suppressor of liver cancer
A protein that typically helps keep cells organized and on task becomes a tumor suppressor in the face of liver cancer, scientists say.
View ArticleCancer metastasis: The unexpected perils of hypoxia
The low oxygen concentrations that prevail in many tumors enhance their propensity to metastasize to other tissues. Researchers at Ludwig-Maximilians-Universitaet (LMU) in Munich led by Professor Heiko...
View ArticlePrototype drug uses novel mechanism to treat lung cancers
Cells are constantly turning proteins on and off via molecular switches—phosphate molecules—that have become common drug targets. in a new study, lung cancer tumors were prevented in mice by a novel...
View ArticleMysterious gene transcripts after cancer therapy
Tumor suppressor genes protect cells from malignant transformation. If they are turned off as a result of chemical modifications in DNA, called epigenetic labels, this contributes to the development of...
View ArticleSpread of breast cancer reduced by targeting acid metabolite
It's a metabolite found in essentially all our cells that, like so many things, cancer overexpresses. Now scientists have shown that when they inhibit 20-HETE, it reduces both the size of a breast...
View ArticleShooting the achilles heel of nervous system cancers
Virtually all cancer treatments used today also damage normal cells, causing the toxic side effects associated with cancer treatment. A cooperative research team led by researchers at Dartmouth's...
View ArticleNew therapeutic approach for difficult-to-treat subtype of ovarian cancer...
A potential new therapeutic strategy for a difficult-to-treat form of ovarian cancer has been discovered by Wistar scientists. The findings were published online in Nature Cell Biology.
View Article'Epigenetic' changes from cigarette smoke may be first step in lung cancer...
Scientists at the Johns Hopkins Kimmel Cancer Center say they have preliminary evidence in laboratory-grown, human airway cells that a condensed form of cigarette smoke triggers so-called "epigenetic"...
View ArticleEditing genes one by one throughout colorectal cancer cell genome uncovers...
Cancers driven by mutations in the KRAS gene are among the most deadly. For decades, researchers have tried unsuccessfully to directly target mutant KRAS proteins as a means to treat tumors. Instead of...
View ArticleBy decoding how HPV causes cancer, researchers find a new potential treatment...
A study that teases apart the biological mechanisms by which human papillomaviruses (HPV) cause cancer has found what researchers at Georgetown University Medical Center say is a new strategy that...
View ArticleNew key regulator of acquisition of immune tolerance to tumor cells in cancer...
Researchers of the Chromatin and Disease Group from the Bellvitge Biomedical Research Institute (IDIBELL) in Barcelona have identified a distinctive epigenetic event in immune cells that differentiate...
View ArticleTeam finds a potentially better way to treat liver cancer
A Keck School of Medicine of USC research team has identified how cancer stem cells survive. This finding may one day lead to new therapies for liver cancer, one of the few cancers in the United States...
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