Scientists identify marker for myeloid-derived suppressor cells
Myeloid-derived suppressor cells (MDSCs) are a population of immune cells that have been implicated in tumor resistance to various types of cancer treatment, including targeted therapies, chemotherapy...
View ArticleWhat can a 1.7-million-year-old hominid fossil teach us about cancer?
In late July, an international team of researchers announced that they had identified evidence of cancer in the fossilized remains of a biological relative of human beings who lived about 1.7 million...
View ArticleImmune cells as biomarkers for idiopathic pulmonary fibrosis
Researchers at Helmholtz Zentrum München, a partner in the German Center for Lung Research (DZL), have discovered that the number of myeloid-derived suppressor cells (MDSC) is increased in the blood of...
View ArticleNew insights into potent cancer tumour suppressor gene
New insight into the function of a gene important in the suppression of cancer is published today. Researchers at the National University of Ireland Galway have shown that the TP53 gene has even...
View ArticleRegulatory RNA essential to DNA damage response
Stanford researchers have found that a tumor suppressor known as p53 is stabilized by a regulatory RNA molecule called DINO. The interaction helps a cell respond to DNA damage and may play a role in...
View ArticleOncoproteins interact to promote cancer cell growth in retinoblastoma
Researchers at The Saban Research Institute of Children's Hospital Los Angeles have identified an unsuspected and critical role of the MDM2 oncogene in promoting expression of the MYCN oncogene that is...
View ArticleAnti-cancer effects found in natural compound derived from onions
Research from Kumamoto University, Japan finds that a natural compound isolated from onions, onionin A (ONA), has several anti-cancer properties for ovarian cancer. This discovery is a result of...
View ArticleMechanism of an effective MEK inhibitor identified
Understanding the effects of certain targeted therapies on antitumor immunity is necessary to design combined interventions for more effective cancer treatment. In the past, data have shown that...
View ArticleResearchers show how a targeted drug overcomes suppressive immune cells
A Ludwig Cancer Research study shows that an experimental drug currently in clinical trials can reverse the effects of troublesome cells that prevent the body's immune system from attacking tumors. The...
View ArticleGene deletion allows cancer cells to thrive when migrating within the brain
Astronauts survive in space by wearing high-tech space suits. But how do brain cancer cells thrive when they migrate to inhospitable sites within the brain?
View ArticleWaking up dormant tumour suppressor genes
A drug-free cancer treatment could teach our genes to destroy the disease from within, according to Western Australian medical researchers.
View ArticleStudy reveals new role for Hippo pathway in suppressing cancer immunity
Previous studies identified the Hippo pathway kinases LATS1/2 as a tumor suppressor, but new research led by University of California San Diego School of Medicine scientists reveals a surprising role...
View ArticleProtein that promotes 'cell-suicide' could revolutionise eye cancer treatment
New research from the University of Liverpool has identified the role of a specific protein in the human body that can help prevent the survival and spread of eye cancer, by initiating cancer...
View ArticleResearchers identify new suppressor effects of the NOX4 protein in liver cancer
Researchers at Bellvitge Biomedical Research Institute (IDIBELL), in collaboration with King's College London, have unveiled the role of NADPH oxidase NOX4 as an inhibitor of the epithelial-amoeboid...
View ArticleThe paradoxical roles of well-known cancer genes are mediated by oxygen...
Oxygen deprivation, or hypoxia, has been identified by A*STAR researchers as a key factor in switching the function of major cancer genes from tumor-promoting to tumor-suppressing in a breast cancer...
View Article'Molecular volume control' may help combat tumours
A 'molecular volume control' may one day be used to manipulate enzyme activity in order control the development and treatment of cancer, according to research at the Universities of Dundee and Bath.
View ArticleNew study shows promise for repurposing anti-malarial drug for cancer treatment
A new study by University of Kentucky Markey Cancer Center researchers shows that chloroquine – a drug currently used to treat malaria – may be useful in treating patients with metastatic cancers.
View ArticleCan myeloid derived suppressor cells subdue viral infections?
Myeloid derived suppressor cells (MDSCs), produced in the bone marrow as part of the human immune response to a tumor, may have a potent immunoregulatory role following viral infection. The...
View ArticleNixing the cells that nix immune response against cancer
Some cells excite the immune system. Others soothe it. Myeloid-derived suppressor cells (MDSCs) are one type of soothing cell, and previous work shows that cancer may specifically boost production of...
View ArticleSpider web of cancer proteins reveals new drug possibilities
Scientists at Winship Cancer Institute of Emory University have mapped a vast spider web of interactions between proteins in lung cancer cells, as part of an effort to reach what was considered...
View Article