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Scrib protein identified as a natural suppressor of liver cancer
A protein that typically helps keep cells organized and on task becomes a tumor suppressor in the face of liver cancer, scientists say.
View ArticleCancer metastasis: The unexpected perils of hypoxia
The low oxygen concentrations that prevail in many tumors enhance their propensity to metastasize to other tissues. Researchers at Ludwig-Maximilians-Universitaet (LMU) in Munich led by Professor Heiko...
View ArticlePrototype drug uses novel mechanism to treat lung cancers
Cells are constantly turning proteins on and off via molecular switches—phosphate molecules—that have become common drug targets. in a new study, lung cancer tumors were prevented in mice by a novel...
View ArticleMysterious gene transcripts after cancer therapy
Tumor suppressor genes protect cells from malignant transformation. If they are turned off as a result of chemical modifications in DNA, called epigenetic labels, this contributes to the development of...
View ArticleSpread of breast cancer reduced by targeting acid metabolite
It's a metabolite found in essentially all our cells that, like so many things, cancer overexpresses. Now scientists have shown that when they inhibit 20-HETE, it reduces both the size of a breast...
View ArticleShooting the achilles heel of nervous system cancers
Virtually all cancer treatments used today also damage normal cells, causing the toxic side effects associated with cancer treatment. A cooperative research team led by researchers at Dartmouth's...
View ArticleNew therapeutic approach for difficult-to-treat subtype of ovarian cancer...
A potential new therapeutic strategy for a difficult-to-treat form of ovarian cancer has been discovered by Wistar scientists. The findings were published online in Nature Cell Biology.
View Article'Epigenetic' changes from cigarette smoke may be first step in lung cancer...
Scientists at the Johns Hopkins Kimmel Cancer Center say they have preliminary evidence in laboratory-grown, human airway cells that a condensed form of cigarette smoke triggers so-called "epigenetic"...
View ArticleEditing genes one by one throughout colorectal cancer cell genome uncovers...
Cancers driven by mutations in the KRAS gene are among the most deadly. For decades, researchers have tried unsuccessfully to directly target mutant KRAS proteins as a means to treat tumors. Instead of...
View ArticleBy decoding how HPV causes cancer, researchers find a new potential treatment...
A study that teases apart the biological mechanisms by which human papillomaviruses (HPV) cause cancer has found what researchers at Georgetown University Medical Center say is a new strategy that...
View ArticleNew key regulator of acquisition of immune tolerance to tumor cells in cancer...
Researchers of the Chromatin and Disease Group from the Bellvitge Biomedical Research Institute (IDIBELL) in Barcelona have identified a distinctive epigenetic event in immune cells that differentiate...
View ArticleTeam finds a potentially better way to treat liver cancer
A Keck School of Medicine of USC research team has identified how cancer stem cells survive. This finding may one day lead to new therapies for liver cancer, one of the few cancers in the United States...
View ArticleTeam explores anti-breast cancer properties of soy
A University of Arizona Cancer Center research team is engaged in a series of studies to investigate how genistein, a component of soy foods, might suppress the development of breast cancer.
View ArticleNew toolkit reveals novel cancer genes
A new statistical model has enabled researchers to pinpoint 27 novel genes thought to prevent cancer from forming, in an analysis of over 2000 tumours across 12 human cancer types. The findings could...
View ArticleCancer research – how a traffic jam causes tumor growth
For tissues to cooperate and perform normal functions, cells need to know which way is up. When cells lose track of their orientation, they can start to grow out of control, and develop into cancer....
View ArticleGenes that hold the clues to bladder cancer and its treatment
Scientists have discovered the 'genetic signatures' of the most common form of bladder cancer - and it could open up the possibility of better-targeted treatment, according to research published today...
View ArticleCellular network identified that 'short circuits' the antitumor effect of...
Researchers from The Wistar Institute discovered a novel form of crosstalk among tumor cells and other cell types in the tumor microenvironment, elucidating the mechanism of action of an...
View ArticleScientists develop a sensor for the most important human cancer gene
If it burns in a house smoke detectors alert us hence protecting life. A molecular smoke alert has now been developed by Dresden researchers for the TP53 gene, the most important human cancer gene. The...
View ArticleResearchers discover a new target for 'triple-negative' breast cancer
So-called "triple-negative" breast cancer is a particularly aggressive and difficult-to-treat form. It accounts for only about 10 percent of breast cancer cases, but is responsible for about 25 percent...
View ArticleResearchers unravel novel mechanism by which tumors grow resistant to...
A Ludwig Cancer Research study has uncovered a key mechanism by which tumors develop resistance to radiation therapy and shown how such resistance might be overcome with drugs that are currently under...
View ArticleImportant tumor suppressor discovered in immune cells
A team from Technical University of Munich has discovered an "emergency shut-off switch" in immune system T cells. Their results could lead to new therapies against T cell non-Hodgkin's lymphoma...
View ArticleTime matters: Does our biological clock keep cancer at bay?
Our body has an internal biological or "circadian" clock, which cycles daily and is synchronized with solar time. New research done in mice suggests that it can help suppress cancer. The study,...
View ArticleNovel compound restores immune response in patients with melanoma
A novel compound may restore immune response in patients with melanoma, according to a study presented at the ESMO Immuno Oncology Congress 2017.
View ArticleNew strategy for unleashing cancer-fighting power of p53 gene
Tumor protein p53 is one of the most critical determinants of the fate of cancer cells, as it can determine whether a cell lives or dies in response to stress. In a new study published today in the...
View ArticleResearchers map molecular interaction that prevents aggressive breast cancer
Researchers in Italy have discovered how specific versions of a protein called Numb protect the key tumor suppressor p53 from destruction. The study, which will be published December 21 in the Journal...
View ArticleNew immunotherapy approach boosts body's ability to destroy cancer cells
Few cancer treatments are generating more excitement these days than immunotherapy—drugs based on the principle that the immune system can be harnessed to detect and kill cancer cells, much in the same...
View ArticleCancer's gene-determined 'immune landscape' dictates progression of prostate...
The field of immunotherapy - the harnessing of patients' own immune systems to fend off cancer - is revolutionizing cancer treatment today. However, clinical trials often show marked improvements in...
View ArticleImmunosuppressive cells in newborns play important role in controlling...
New research led by The Wistar Institute, in collaboration with Sun Yat-sen University in China, has characterized the transitory presence of myeloid-derived suppressor cells (MDSCs) in mouse and human...
View ArticleGene duplication explains tumor aggressiveness
Pancreatic cancer is a form of cancer associated with the highest mortality rates in the world. Genetic changes that could explain its aggressiveness and early metastasis are elusive. A team at...
View ArticleStudy shows liver cells with whole genome duplications protect against cancer
Researchers at the Children's Medical Center Research Institute (CRI) at UT Southwestern have discovered that cells in the liver with whole genome duplications, known as polyploid cells, can protect...
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