Cells are constantly turning proteins on and off via molecular switches—phosphate molecules—that have become common drug targets. in a new study, lung cancer tumors were prevented in mice by a novel small molecule that directly activates a tumor suppressor protein. Dr. Goutham Narla of Case Western Reserve University says, "All the drugs we currently have to treat our cancer patients target what we call kinases, which attach phosphate molecules to proteins. But equally important to this are the enzymes that take the phosphate off."
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