Study suggests new role for gene in suppressing cancer
Scientists at The University of Manchester have discovered that a previously known gene also helps cells divide normally and that its absence can cause tumours.
View ArticleNew method characterizes structure of protein that promotes tumor growth
Moffitt Cancer Center researchers have developed a new method to identify a previously unknown structure in a protein called MDMX. MDMX is a crucial regulatory protein that controls p53 - one of the...
View ArticleResearchers discover an inactive tumor suppressor gene in lung cancer
Researchers at Genes and Cancer group at Bellvitge Biomedical Research Institute (IDIBELL), led by Montse Sanchez-Cespedes, have identified the PARD3 gene as a tumor suppressor that is inactivated in...
View ArticleToxic mushroom-based drug may help battle colorectal cancer
For some time, cancer scientists have considered the toxin, alpha-amanatin derived from "death cap" mushrooms, as a possible cancer treatment. However, due to its penchant for causing liver toxicity,...
View ArticleStudy illuminates role of cancer drug decitabine in repairing damaged cells
A Purdue University study sheds light on how cell damage is reversed by the cancer drug decitabine and identifies a potential biomarker that could indicate a patient's stage of cancer and response to...
View ArticlePactamycin analogs offer new, gentler approach to cancer treatment
Researchers at Oregon State University are pursuing a new concept in treatment of epithelial cancer, especially head and neck cancer, by using two promising "analogs" of an old compound that was once...
View ArticleA single gene turns colorectal cancer cells back into normal tissue in mice
Anti-cancer strategies generally involve killing off tumor cells. However, cancer cells may instead be coaxed to turn back into normal tissue simply by reactivating a single gene, according to a study...
View ArticleProtein's impact on colorectal cancer is dappled
Researchers at University of California, San Diego School of Medicine have discovered a cell signaling pathway that appears to exert some control over initiation and progression of colorectal cancer,...
View ArticleStudy finds that a protein that helps suppress cancer fades as we age
Researchers at UCLA have found that a protein that serves as a suppressor of cancer diminishes in skin and mouth epithelial cells as the human body ages.
View ArticleScientists identify key genetic factor that keeps moles from turning into...
Moles are benign tumors found on the skin of almost every adult. Scientists have known for years that a mutation in the BRAF gene makes them start growing, but until now haven't understood why they...
View ArticleTumour suppressor genes curb growth in neighbouring cells
Researchers at IRB Barcelona unravel a role for tumour suppressor genes in restricting the growth of neighbouring cell populations. The study, published yesterday in PloS Biology, might have...
View ArticleMushroom powder shows potential in prostate cancer
(HealthDay)—For patients with biochemically recurrent prostate cancer, treatment with white button mushroom (WBM) powder may reduce prostate-specific antigen (PSA) levels, according to a study...
View ArticleBlood cancers develop when immune cell DNA editing hits off-target spots
Sometimes when the immune system makes small mistakes, the body amplifies its response in a big way: Editing errors in the DNA of developing T and B cells can cause blood cancers. Now, researchers from...
View ArticleBrazil's cancer curse
The startling discovery that hundreds of thousands of Brazilians have a genetic mutation that undermines their ability to resist cancer is helping labs worldwide in their search for new treatments for...
View Article'Reversible' tumor suppressor loss: Key to new brain cancer therapies?
It's no surprise that people enjoy warm places like Hawaii but may suffer in hostile locales such as Antarctica. A tumor suppressor gene called PTEN is similar in that it is affected by the...
View ArticleScientists show how frequently mutated prostate cancer gene suppresses tumors
The gene SPOP is mutated in up to 15 percent of all cases of prostate cancer, making it one of the most mutated genes in the disease. However, when the gene is functioning properly, it acts as a tumor...
View ArticleA newly discovered tumor suppressor gene affects melanoma survival
Of the hundreds of genes that can be mutated in a single case of melanoma, only a handful may be true "drivers" of cancer. In research that appeared last week in Nature Genetics, a Weizmann Institute...
View ArticleNew class of RNA tumor suppressors identified
A pair of RNA molecules originally thought to be no more than cellular housekeepers are deleted in over a quarter of common human cancers, according to researchers at the Stanford University School of...
View ArticleCausal link between aneuploidy and cancer
One of the key unresolved question in cancer is whether aneuploidy, as defined by the presence of gain or loss of chromosomes, is the cause or the consequence of cancer development. Since the...
View ArticleImportant step toward preventing and treating some MRSA post-implant infections
New research published in the Journal of Leukocyte Biology, helps explain why Staphylococcus aureus infections take hold after prosthetic surgery that are resistant to both the body's natural defenses...
View Article