A metabolic pathway that is up-regulated in certain breast cancers promotes the disease's progression by activating a cell signaling protein called Arf6, according to a paper published in the Journal of Cell Biology. The study, "P53- and mevalonate pathway-driven malignancies require Arf6 for metastasis and drug resistance" by Ari Hashimoto and colleagues, has been published online ahead of print and suggests that statin-like drugs may be effective treatments for breast cancer patients whose tumors express high levels of Arf6 signaling proteins.
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