A team of scientists, comprising researchers from the Institute of Molecular and Cell Biology (IMCB), a research institute under the Agency for Science, Technology and Research (A*STAR), Singapore, and the VIB Laboratory of Molecular Cancer Biology (VIB/KU Leuven), has revealed the mechanism by which tumor cells elevate levels of MDM4, a protein that is highly expressed in cancer cells but not in normal adult tissues. The team has also found that the mechanism can be interfered with antisense oligonucleotides (ASOs) to suppress cancer growth. The study which paves the way for the development of novel cancer therapeutics was published in the leading Journal of Clinical Investigation (JCI).
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